Performance Comparison of Thiophene Derivative Films for SPR-Based Creatinine Detection

Authors

  • Nur Afifah Ahmad Nazri Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia,
  • Nur Hidayah Azeman Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia,
  • Nur Izzah Zakaria Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, https://orcid.org/0009-0000-5059-9611
  • Muhammad Asif Ahmad Khusaini Faculty of Science and Technology, Universiti Kebangsaan Malaysia
  • Mohd Hafiz Abu Bakar Institute of Power Engineering, Universiti Tenaga Nasional
  • Tengku Hasnan Tengku Abdul Aziz Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia,
  • Ahmad Ashrif A Bakar Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, https://orcid.org/0000-0002-9060-0346
  • Ahmad Rifqi Md Zain Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, https://orcid.org/0000-0002-4611-341X

DOI:

https://doi.org/10.53655/joe.m6577r

Keywords:

Creatinine, SPR, Thiophene

Abstract

This study presents a comparative SPR analysis of tetrahydrothiophene (THT) and benzo[b]thiophene-2-carboxaldehyde (BTCA) as sensing layers for creatinine detection. Using an SPR setup, both materials exhibited concentration-dependent spectral shifts. The BTCA-based sensor demonstrated higher sensitivity (3.3557 nm/(mg/dL)), better linearity (R² = 0.9636), and lower detection limits than THT, attributed to stronger molecular interactions, including hydrogen bonding and dipole-dipole effects. These results confirm BTCA's superior plasmonic response, supporting its potential as a label-free sensing material for creatinine detection in clinical diagnostics.

References

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H.S. Biswal, Hydrogen Bonds Involving Sulfur: New Insights from ab Initio Calculations and Gas Phase Laser Spectroscopy, Challenges and Advances in Computational Chemistry and Physics 19 (2015) 15–45. https://doi.org/10.1007/978-3-319-14163-3_2.

X. Chen, G. Wang, X. Zeng, W. Li, M. Zhou, Unveiling the Role of Water on π-π Stacking Through Microwave Spectroscopy of (Thiophene)2-(Water)1-2 Clusters, J Am Chem Soc 146 (2024). https://doi.org/10.1021/jacs.3c10887.

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Published

30-10-2025

How to Cite

Nazri, N. A. A., Azeman, N. H., Zakaria, N. I. ., Khusaini, M. A. A., Bakar, M. H. A., Aziz, T. H. T. A., Bakar, A. A. A., & Zain, A. R. M. (2025). Performance Comparison of Thiophene Derivative Films for SPR-Based Creatinine Detection . Jurnal OptoElektronik, 1–3. https://doi.org/10.53655/joe.m6577r

Issue

Volume 4 (2025)

Section

TMP2025: Regular

License

Copyright (c) 2025 Nur Afifah Ahmad Nazri, Nur Hidayah Azeman, Nur Izzah Zakaria, Muhammad Asif Ahmad Khusaini, Mohd Hafiz Abu Bakar, Tengku hasnan Tengku Abdul Aziz, Ahmad Ashrif A Bakar, Ahmad Rifqi Md Zain

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