Comparative Study on Carbon Dots and Carboxyl-Carbon Dots - LSPR for Creatinine Detection

Authors

  • Athiyah Sakinah Masran Department of Electrical, Electronic, and Systems Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
  • Nur Hidayah Azeman Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
  • Nur Afifah Ahmad Nazri Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
  • Azween Hadiera Hishamuddin School of Electrical Engineering, College of Engineering, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia. https://orcid.org/0009-0005-7487-0660
  • Mohd Hafiz Abu Bakar Institute of Power Engineering, Universiti Tenaga Nasional,43000 Kajang, Selangor, UNITEN, Malaysia. https://orcid.org/0000-0003-1035-1042
  • Muhammad Qayyum Othman Photonics Technology Laboratory, Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia. https://orcid.org/0009-0006-5037-3579
  • Rozita Sulaiman Photonics Technology Laboratory, Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia. https://orcid.org/0000-0003-3993-5324
  • Ahmad Ashrif A Bakar Photonics Technology Laboratory, Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.

DOI:

https://doi.org/10.53655/joe.t7402m

Keywords:

Carbon dots, Carboxyl carbon dots, SPR, Creatinine, Optical sensor

Abstract

The detection of creatinine, a crucial biomarker for kidney function, has attracted significant attention due to the need for rapid and sensitive detection. In this study, we report a comparative analysis of Carbon Dots (CDs) and Carboxyl-Carbon Dots (CDsCOO) for developing a fluorescent-based creatinine sensor. Both carbon dots were synthesized via a hydrothermal approach, with surface modification introduced to generate carboxyl functional groups in CDsCOO. Creatinine sensing performance was evaluated based on the fluorescence quenching response, calibration curve linearity, sensitivity, and limit of detection (LOD). The effectiveness of this material was evaluated at concentrations ranging from 0 to 0.6 mg/dL. The CDsCOO demonstrated superior performance with enhanced sensitivity and a lower LOD than unmodified CDs, achieving a LOD of approximately [0.05 mg/dL & 0.28 mg/dL] and a sensitivity of [20.123 ndL/g & 3.696 ndL/g]. This work highlights the potential of CDsCOO as a promising platform for efficient and selective creatinine detection.

References

B. P. Nanda, P. Rani, P. Paul, Aman, S. S. Ganti, and R. Bhatia, “Recent trends and impact of localized surface plasmon resonance (lspr) and surface-enhanced raman spectroscopy (sers) in modern analysis,” Journal of Pharmaceutical Analysis, vol. 14, no. 11, p. 100 959, Nov. 2024, ISSN: 2095-1779. DOI:10.1016/j.jpha.2024.02.013

A. S. Masran et al., “Sensitivity improvement of creatinine detection based on functionalized carbon dots and silver nanotriangular localized surface plasmon resonance,” Plasmonics, Jan. 2025, ISSN: 1557-1963. DOI:10.1007/s11468-024-02739-x

N. H. Azeman et al., “Carboxymethyl chitosan/graphene oxide/silver nanotriangles nanohybrid as the sensing materials for the enhancement of ammonia localized surface plasmon resonance sensor,” Optics

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Published

02-11-2025

How to Cite

Masran, A. S., Azeman, N. H. ., Ahmad Nazri, N. A. ., Hishamuddin, A. H. ., Abu Bakar, M. H., Othman, M. Q., Sulaiman, R. ., & A Bakar, A. A. (2025). Comparative Study on Carbon Dots and Carboxyl-Carbon Dots - LSPR for Creatinine Detection. Jurnal OptoElektronik, 1–3. https://doi.org/10.53655/joe.t7402m

Issue

Volume 4 (2025)

Section

TMP2025: Regular

License

Copyright (c) 2025 Athiyah Sakinah Masran, Nur Hidayah Azeman, Nur Afifah Ahmad Nazri, Azween Hadiera Hishamuddin, Mohd Hafiz Abu Bakar, Muhammad Qayyum Othman, Rozita Sulaiman, Ahmad Ashrif A Bakar

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